Hi all,

I have a sample of 24 participants, each with pre- and post-intervention resting-state data. Now I want to see if there are differences between pre- and post-intervention in my ROI-to-ROI analyses without having a hypothesis about directionality. I have read that you can use contrast [1 1] for this purpose (which would be a custom contrast in CONN). Is this correct? I also got some results and wanted to investigate them further to see if there was an increase or decrease between pre and post and then got no results at all. Could this be the case and if so, why?

Thank you all!

Best,

Max