Hi Lara,



Sorry it has taken so long. I actually had to dig this information back from the code.

My personal way to figure out the direction of the differences of the P-value maps is by looking at meanA and meanB combined morphologies (in Slicer, for example) and making comparisons with the P-value maps.,Mean A and mean B are created by averaging each files of each group for the first group type (in your case "diagnosis"), and I dont think the program has any special way to create meanA and meanB. You could use MeshMath distributed with SPHARM to average your files according to group_type 0 (diagnosis) and group_type 1 (gender) and see what your actual meanA and meanB look like compared to those. I am sure that computing p-values is done with the GLM including all variables for testing.

Another way to check directionality of differences, is the DiffMagnitude file, but even so I am not so sure what that files means in your case, since it is just an arithmetic subtraction of meanB to meanA so I dont think its something you can use to figure out the directionality of the changes.


I am sorry I am still unsure about this question. I will check with Martin and get back to you asap.


Thank you,

Beatriz