================================================ MGH Neonatal/Pediatric ADC Atlases (0-6 years) ================================================ ------------------------- Reference ------------------------- Y Ou, N Reynolds, R Gollub,, R Pienaar, Y Wang, T Wang, D Sack, K Andriole, S Pieper, C Herrick, S Murphy, P Grant, L Zollei, "Developmental Brain ADC Atlas Creation From Clinical Images". Organization for Human Brain Mapping (OHBM). (2014) [PDF: http://www.nmr.mgh.harvard.edu/~you2/publications/BabyAtlasing_OHBM14.pdf] -------------------------- Population and Age Groups -------------------------- Totally 308 ADC maps from 308 subjects were queried and collected using the mi2b2 workbench (https://www.nmr.mgh.harvard.edu/lab/mi2b2). These subjects were divided into the following 10 age groups: - neonates (first 2 weeks of life) - the rest of the quarter 1 - quarter 2 - quarter 3 - quarter 4 - year 1-2 - year 2-3 - year 3-4 - year 4-5 - year 5-6 ------------------------- Atlases Reconstruction ------------------------- In each age group, all ADC maps were group-wise registered to create a (virtual) space representing the mean anatomy/geometry of all subjects in this age group. In this mean space (atlas space), we have derived the voxel-wise mean ADC values (the atlas) and the voxel-wise standard deviation ADC values. We released all atlases (mean and stdev maps) in its original space and rigidly aligned in the year1-2 atlas space. ------------------------- Imaging Protocol ------------------------- Diffusion weighted images were acquired on a Siemens Trio 3T scanner at MGH. The imaging protocol  was: time of repetition (TR) – 7500~9500 ms, echo time (TE) – 80~115 ms, b value – 1000 s/mm2, image  size – 256x256x60 voxels, voxel size – 0.86x0.86x2.0 mm3. ADC maps were generated by scannerembedded diffusion tensor imaging software. We directly used them in our study.