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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Hi Jonathan,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Thanks for your reply. I used “intracellular volume fraction” = “icvf”.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Here is a list of all the substrate geometric properties used for the data in the graphic:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="519" style="width:389.0pt;margin-left:-.75pt;border-collapse:collapse">
<tbody>
<tr style="height:45.0pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:45.0pt">
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">radius, r<o:p></o:p></span></b></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:45.0pt">
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">axonal spacing, a<o:p></o:p></span></b></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:45.0pt">
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">diameter<o:p></o:p></span></b></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:45.0pt">
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">a/r<o:p></o:p></span></b></p>
</td>
<td width="135" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:45.0pt">
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">intracellular volume fraction, icvf<o:p></o:p></span></b></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.967E-08<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.082E-07<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.193E-07<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.52<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.05<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.375E-07<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.875E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.750E-07<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.52<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.05<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.350E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.150E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.700E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.52<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.05<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.400E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">4.600E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.080E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.52<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.05<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.055E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.602E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.110E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.52<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.05<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">4.505E-07<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.108E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">9.009E-07<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">9.009E-07<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.215E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.802E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.802E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">4.431E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.604E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.604E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.861E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.208E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.208E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.772E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.442E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.442E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.544E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.883E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.883E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.089E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.766E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.766E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.418E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.153E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.153E-04<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.836E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.306E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.185E-07<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.832E-07<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.371E-07<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.371E-07<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.566E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.274E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.274E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.133E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.548E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.548E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.266E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.096E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.096E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.253E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.019E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.019E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.506E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.039E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.039E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.013E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">4.077E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">4.077E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.003E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.154E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.154E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.005E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.631E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.631E-04<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">4.010E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.262E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.46<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.6<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.502E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.235E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.004E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.004E-06<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.447E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.401E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.401E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.894E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.802E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.802E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.788E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.604E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">5.604E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.158E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.121E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.121E-04<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.315E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.241E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.191E-07<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.279E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">1.238E-06<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.962E-05<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">8.186E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">7.925E-05<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
<tr style="height:14.25pt">
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">3.170E-04<o:p></o:p></span></p>
</td>
<td width="120" nowrap="" valign="bottom" style="width:90.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.548E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">6.340E-04<o:p></o:p></span></p>
</td>
<td width="88" nowrap="" valign="bottom" style="width:66.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">2.07<o:p></o:p></span></p>
</td>
<td width="135" nowrap="" valign="bottom" style="width:101.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.25pt">
<p class="MsoNormal" align="right" style="text-align:right"><span style="font-size:11.0pt;font-family:"Arial","sans-serif";color:black">0.85<o:p></o:p></span></p>
</td>
</tr>
</tbody>
</table>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Thanks,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">David<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm">
<p class="MsoNormal"><b><span lang="FR" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">De :</span></b><span lang="FR" style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> jonhrafe@gmail.com [mailto:jonhrafe@gmail.com]
<b>De la part de</b> Jonathan Rafael Patino<br>
<b>Envoyé :</b> 18 September 2014 21:18<br>
<b>À :</b> Slater David<br>
<b>Cc :</b> camino-users@www.nitrc.org<br>
<b>Objet :</b> Re: [Camino-users] Unexpected Monte Carlo Diffusion Simulations<o:p></o:p></span></p>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif"">Hi David. <o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif"">I don't really have an explanation for the weird behavior of the radial diffusivity. Can you tell us the set of radius and separation values that you used in your experiments? I would
like to visualize the trajectories of the spins in each simulation.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif"">Another thing, in your graphic, what's the meaning of "icvf"? I'm not familiar with the concept.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial","sans-serif""></span><span style="font-family:"Arial Narrow","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif"">Best!<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="font-family:"Arial","sans-serif""></span><span style="font-family:"Arial Narrow","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal">2014<o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Arial","sans-serif""></span><span style="font-family:"Arial Narrow","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial","sans-serif""></span><span style="font-family:"Arial Narrow","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial","sans-serif""></span><span style="font-family:"Arial Narrow","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial","sans-serif""></span><span style="font-family:"Arial Narrow","sans-serif""><o:p></o:p></span></p>
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<p class="MsoNormal">-09-16 10:34 GMT-05:00 Slater David <<a href="mailto:David.Slater@chuv.ch" target="_blank">David.Slater@chuv.ch</a>>:<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Hi everyone,<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">I’ve been working with the Camino Monte Carlo diffusion simulator. To check things were working correctly I tried some simple tests of diffusion around hexagonally packed cylinders.
Spins were placed only in the extracellular space by using the ‘extra’ option. However even with these simple tests I’ve got some unexpected results.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">I created a number of substrates with different axon radii while keeping the ratio of cylinder separation to axon radius constant. In this way we scale up and down the characteristic
length scales of the system while keeping the intra- and extra-cellular volume fractions constant.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">By applying the same scheme to each substrate with (Δ-δ/3)=30ms we would expect radial diffusivity to approach free diffusivity in systems with very large length scales (i.e. relatively
few membrane interactions) while radial diffusivity should approximate theoretical tortuosity model predictions in systems with very small characteristic length scales.
<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">In fact what we find from the simulations is that radial diffusivity can go
<i>up</i> as the axon radius and axonal spacing go <i>down</i>. See the attached figure. This seems physically implausible to me: how is it that extracellular diffusivity can increase in systems with more membranes per unit length?<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Here are example commands that I used to create the .traj files and to generate the synthetic measurements:<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">datasynth -walkers 200000 -tmax 5000 -p 0 -voxels 1 -initial extra -duration 0.04 -diffusivity 17E-10 -substrate cylinder -packing hex -cylinderrad 9.01E-07 -cylindersep 2.22E-06
-trajfile ic60_diam1p8E-06_extra_hex_dura40ms.traj<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">scan -trajfile ic60_diam1p8E-06_extra_hex_dura40ms.traj -schemefile J30_DELTA30.scheme2 | float2txt > ic60_diam1p8E-06_extra_hex_dura40ms_J30_DELTA30.txt<o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">I have also attached the .scheme2 file that was used.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">What might be leading to these unexpected results? Do you have any suggestions for where I might be going wrong?<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Any help or suggestions will be greatly appreciated.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Thanks,<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">David<o:p></o:p></p>
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