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INSTALLATION

From Source

 svn checkout https://www.nitrc.org/svn/createdwiatlas

1. Use cmake to generate the Makefile:

 createdwiatlas/ > ccmake .

and hit 'c'. It will ask for a local Slicer3 installation. Set SLICER_DIR to point to where your Slicer3-build is located, and hit 'c' again. Then hit 'g' to generate the Makefile. 'q' to quit.

2. Run make

At the terminal, type 'make':

 createdwiatlas/ > make

3. Test the binaries

Once the source has compiled, you can test the binaries by typing 'make test':

 createdwiatals/ > make test

This checks that each binary exists and that they successfully run with the flags '--help' and '--version'.

4. Test the modules

Each module has a test folder with one or more test scripts within. To test the modules, you can run these scripts. They also show how to run the modules from the commandline.

As a Slicer extension

(Once the modules are registered as Slicer extensions you will be able to download them directly from Slicer)



DOCUMENTATION

Each module corresponds to a step in creating a DWI Atlas:

1. Groupwise Registration: Co-register a set of subjects using their FA maps

2. Warp DWI's: Use the deformations computed by the registration to warp each subject's DWI

3. Average DWI's: Average the set of warped DWI's to produce the final DWI atlas


1. Groupwise Log Domain Symmetric Registration

IO
Images from which the atlas will be created These must be 3D images, for example, FA maps
Output Directory Where the intermediate and result images will be saved
Output Image suffix
Registration Parameters
Number of Outer Iterations  The number of times the set of images are registered to a template
Levels  The number of levels in the multi-resolution pyramid used to compute the registration from an image to the template
Number of Iterations per level  The number of iterations used to compute the registration for each level of the multi-resolution pyramid
Starting smoothness of deformation  Parameter that specifies amount of smoothing in the begining of the registration process
Final smoothness of deformation  Parameter that specifies the amount of smoothing at the end of the registration process
Inversely proportional to gradient step size  Parameter to specify the gradient step size


2. Warp DWI's

IO
Input Image A 3D image or 4D DWI image
Warp Image A 4D deformation image
Output Image
Resample at a) Canonical b) Original The gradient directions of the output image
Save the output image without the baseline slices? An option to save the output image without the B0 slices

3. Average DWI's

IO
DWI's from which to create average DWI A set of 3D images or 4D DWI images
Output Image
Create New DiffusionWeightedVolume


REFERENCES

Bouix, S., Rathi, Y., Sabuncu, M. "Building an Average Population HARDI Atlas"

Mert R. Sabuncu, B.T. Thomas Yeo , Koen Van Leemput, Tom Vercauteren, and Polina Golland1, "Asymmetric Image-Template Registration"

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