http://www.nitrc.org/forum/forum.php?forum_id=2639 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping.</b></p> <p>Neuroimage. 2012 Feb 10;</p> <p>Authors: Eggebrecht AT, White BR, Ferradal SL, Chen C, Zhan Y, Snyder AZ, Dehghani H, Culver JP</p> <p>Abstract<br/> Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxel-to-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subject-specific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4+/-1mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.<br/> </p><p>PMID: 22330315 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 26 Apr 2026 4:41:37 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator