http://www.nitrc.org/forum/forum.php?forum_id=3025 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Test-retest stability analysis of resting brain activity revealed by blood oxygen level-dependent functional MRI.</b></p> <p>J Magn Reson Imaging. 2012 Apr 25;</p> <p>Authors: Li Z, Kadivar A, Pluta J, Dunlop J, Wang Z</p> <p>Abstract<br/> PURPOSE: To assess test-retest stability of four functional magnetic resonance imaging (fMRI)-derived resting brain activity metrics: the seed-region-based functional connectivity (SRFC), independent component analysis (ICA)-derived network-based FC (NTFC), regional homogeneity (ReHo), and the amplitude of low frequency fluctuation (ALFF). METHODS: Simulations were used to assess the sensitivity of SRFC, ReHo, and ALFF to noise interference. Repeat resting blood oxygen level-dependent (BOLD) fMRI were acquired from 32 healthy subjects. The intraclass correlation coefficient (ICC) was used to assess the stability of the four metrics. RESULTS: Random noise yielded small random SRFC, small but consistent ReHo and ALFF. A neighborhood size greater than 20 voxels should be used for calculating ReHo in order to reduce the noise interference. Both the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC)-based SRFC were reproducible in more spatially extended regions than ICA NTFC. The two regional spontaneous brain activity (SBA) measures, ReHo and ALFF, showed test-retest reproducibility in almost the whole gray matter. CONCLUSION: SRFC, ReHo, and ALFF are robust to random noise interference. The neighborhood size for calculating ReHo should be larger than 20 voxels. ICC &gt; 0.5 and cluster size &gt; 11 should be used to assess the ICC maps for ACC/PCC SRFC, ReHo, and ALFF. BOLD fMRI-based SBA can be reliably measured using ACC/PCC SRFC, ReHo, and ALFF after 2 months. J. Magn. Reson. Imaging 2012;. ©2012 Wiley Periodicals, Inc.<br/> </p><p>PMID: 22535702 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Tue, 28 Apr 2026 4:10:46 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator