http://www.nitrc.org/forum/forum.php?forum_id=3030 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Localizing Seizure-Onset Zones in Presurgical Evaluation of Drug-Resistant Epilepsy by Electroencephalography/fMRI: Effectiveness of Alternative Thresholding Strategies.</b></p> <p>AJNR Am J Neuroradiol. 2012 Apr 26;</p> <p>Authors: Hauf M, Jann K, Schindler K, Scheidegger O, Meyer K, Rummel C, Mariani L, Koenig T, Wiest R</p> <p>Abstract<br/> BACKGROUND AND PURPOSE:Simultaneous EEG/fMRI is an effective noninvasive tool for identifying and localizing the SOZ in patients with focal epilepsy. In this study, we evaluated different thresholding strategies in EEG/fMRI for the assessment of hemodynamic responses to IEDs in the SOZ of drug-resistant epilepsy.MATERIALS AND METHODS:Sixteen patients with focal epilepsy were examined by using simultaneous 92-channel EEG and BOLD fMRI. The temporal fluctuation of epileptiform signals on the EEG was extracted by independent component analysis to predict the hemodynamic responses to the IEDs. We applied 3 different threshold criteria to detect hemodynamic responses within the SOZ: 1) PA, 2) a fixed threshold at P &lt; .05 corrected for multiple comparison (FWE), and 3) FAV (4000 ± 200 activated voxels within the brain).RESULTS:PA identified the SOZ in 9 of 16 patients; FWE resulted in concordant BOLD signal correlates in 11 of 16, and FAV in 13 of 16 patients. Hemodynamic responses were detected within the resected areas in 5 (PA), 6 (FWE), and 8 (FAV) of 10 patients who remained seizure-free after surgery.CONCLUSIONS:EEG/fMRI is a noninvasive tool for the presurgical work-up of patients with epilepsy, which can be performed during seizure-free periods and is complementary to the ictal electroclinical assessment. Our findings suggest that the effectiveness of EEG/fMRI in delineating the SOZ may be further improved by the additional use of alternative analysis strategies such as FAV.<br/> </p><p>PMID: 22538072 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Mon, 27 Apr 2026 1:25:04 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator