http://www.nitrc.org/forum/forum.php?forum_id=3136 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Clinical Standardized fMRI Reveals Altered Language Lateralization in Brain Tumor Patients.</b></p> <p>AJNR Am J Neuroradiol. 2012 May 17;</p> <p>Authors: Partovi S, Jacobi B, Rapps N, Zipp L, Karimi S, Rengier F, Lyo JK, Stippich C</p> <p>Abstract<br/> BACKGROUND AND PURPOSE:Brain tumors affecting language-relevant areas may influence language lateralization. The purpose of this study was to systematically investigate language lateralization in brain tumor patients using clinical language fMRI, comparing the results with a group of healthy volunteers.MATERIALS AND METHODS:Fifty-seven strictly right-handed patients with left-hemispheric-space intracranial masses (mainly neoplastic) affecting either the Broca area (n = 19) or Wernicke area (n = 38) were prospectively enrolled in this study. Fourteen healthy volunteers served as a control group. Standardized clinical language fMRI, using visually triggered sentence- and word-generation paradigms, was performed on a 1.5T MR scanner. Semiautomated analyses of all functional data were conducted on an individual basis using BrainVoyager. A regional lateralization index was calculated for Broca and Wernicke areas separately versus their corresponding right-hemisphere homologs.RESULTS:In masses affecting the Broca area, a significant decrease in the lateralization index was found when performing word generation (P = .0017), whereas when applying sentence generation, the decrease did not reach statistical significance (P = .851). Masses affecting the Wernicke area induced a significant decrease of the lateralization index when performing sentence generation (P = .0007), whereas when applying word generation, the decrease was not statistically significant (P = .310).CONCLUSIONS:Clinical language fMRI was feasible for patients with brain tumors and provided relevant presurgical information by localizing essential language areas and determining language dominance. A significant effect of the brain masses on language lateralization was observed, with a shift toward the contralesional, nondominant hemisphere. This may reflect compensatory mechanisms of the brain to maintain communicative abilities.<br/> </p><p>PMID: 22595902 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Tue, 28 Apr 2026 5:31:01 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator