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  <title>NITRC News Group Forum: a-systematic-review-of-resting-state-functional-mri-studies-in-major-depression.</title>
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        &lt;p&gt;&lt;b&gt;A systematic review of resting-state functional-MRI studies in major depression.&lt;/b&gt;&lt;/p&gt;
        &lt;p&gt;J Affect Disord. 2012 Jul 31;&lt;/p&gt;
        &lt;p&gt;Authors:  L W, D F H, I B H, J L&lt;/p&gt;
        &lt;p&gt;Abstract&lt;br/&gt;
        BACKGROUND: To evaluate the literature pertaining to the use of resting-state functional magnetic resonance imaging (fMRI) in Major Depression (MD). METHODS: A search for papers published in English was conducted using MedLine, Embase, PsycINFO, OvidSP, and ScienceDirect with the following words: resting state, depression, MRI, affective, and default-mode. RESULTS: The findings from 16 resting-state fMRI studies on MD are tabulated. Some common findings are discussed in further detail. CONCLUSION: The use of resting-state fMRI in MD research has yielded a number of significant findings that provide the basis for understanding the pathophysiology of depressive symptoms. Of particular note and deserving of further research are the roles of the cortico-limbic mood regulating circuit (MRC) and the interaction between task-positive and task-negative networks in MD. There is increasing interest in the use of resting-state fMRI in the study of psychiatric conditions, and continued improvement in technique and methodology will prove valuable in future research.&lt;br/&gt;
        &lt;/p&gt;&lt;p&gt;PMID: 22858266 [PubMed - as supplied by publisher]&lt;/p&gt;
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