http://www.nitrc.org/forum/forum.php?forum_id=3468 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study.</b></p> <p>J Psychiatry Neurosci. 2012 Aug 14;37(5):110187</p> <p>Authors: Otti A, Guendel H, Henningsen P, Zimmer C, Wohlschlaeger AM, Noll-Hussong M</p> <p>Abstract<br/> Background: Without stimulation, the human brain spontaneously produces highly organized, low-frequency fluctuations of neural activity in intrinsic connectivity networks (ICNs). Furthermore, without adequate explanatory nociceptive input, patients with somatoform pain disorder experience pain symptoms, thus implicating a central dysregulation of pain homeostasis. The present study aimed to test whether interactions among pain-related ICNs, such as the default mode network (DMN), cingular-insular network (CIN) and sensorimotor network (SMN), are altered in somatoform pain during resting conditions. Methods: Patients with somatoform pain disorder and healthy controls underwent resting functional magnetic resonance imaging that lasted 370 seconds. Using a data-driven approach, the ICNs were isolated, and the functional network connectivity (FNC) was computed. Results: Twenty-one patients and 19 controls enrolled in the study. Significant FNC (p &lt; 0.05, corrected for false discovery rate) was detected between the CIN and SMN/anterior DMN, the anterior DMN and posterior DMN/SMN, and the posterior DMN and SMN. Interestingly, no group differences in FNC were detected. Limitations: The most important limitation of this study was the relatively short resting state paradigm. Conclusion: To our knowledge, our results demonstrated for the first time the resting FNC among pain-related ICNs. However, our results suggest that FNC signatures alone are not able to characterize the putative central dysfunction underpinning somatoform pain disorder.<br/> </p><p>PMID: 22894821 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Fri, 01 May 2026 3:44:58 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator