NITRC News Group Forum: focusdet--a-new-toolbox-for-siscom-analysis.-evaluation-of-the-registration-accuracy-using-monte-carlo-simulation

NITRC News Group Forum: focusdet--a-new-toolbox-for-siscom-analysis.-evaluation-of-the-registration-accuracy-using-monte-carlo-simulation http://www.nitrc.org/forum/forum.php?forum_id=3476 <div class="Abstract" lang="en"><a name="Abs1"></a>Abstract  <div class="normal">Subtraction of Ictal SPECT Co-registered to MRI (SISCOM) is an imaging technique used to localize the epileptogenic focus in patients with intractable partial epilepsy. The aim of this study was to determine the accuracy of registration algorithms involved in SISCOM analysis using FocusDET, a new user-friendly application. To this end, Monte Carlo simulation was employed to generate realistic SPECT studies. Simulated sinograms were reconstructed by using the Filtered BackProjection (FBP) algorithm and an Ordered Subsets Expectation Maximization (OSEM) reconstruction method that included compensation for all degradations. Registration errors in SPECT-SPECT and SPECT-MRI registration were evaluated by comparing the theoretical and actual transforms. Patient studies with well-localized epilepsy were also included in the registration assessment. Global registration errors including SPECT-SPECT and SPECT-MRI registration errors were less than 1.2 mm on average, exceeding the voxel size (3.32 mm) of SPECT studies in no case. Although images reconstructed using OSEM led to lower registration errors than images reconstructed with FBP, differences after using OSEM or FBP in reconstruction were less than 0.2 mm on average. This indicates that correction for degradations does not play a major role in the SISCOM process, thereby facilitating the application of the methodology in centers where OSEM is not implemented with correction of all degradations. These findings together with those obtained by clinicians from patients via MRI, interictal and ictal SPECT and video-EEG, show that FocusDET is a robust application for performing SISCOM analysis in clinical practice. </div> </div><ul> <li>Content Type Journal Article</li><li>Category Original Article</li><li>Pages 1-13</li><li>DOI 10.1007/s12021-012-9158-x</li><li>Authors<ul> <li>Berta Martí Fuster, Unitat de Biofísica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, C/Casanova 143 – Planta 5 (Ala Nord), E08036 Barcelona, Spain</li><li>Oscar Esteban, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain</li><li>Xavier Planes, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain</li><li>Pablo Aguiar, Servizo de Medicina Nuclear, Fundación IDICHUS, Complexo Hospitalario Universitario de Santiago de Compostela, Rúa da Choupana s/n, E15706 Santiago de Compostela, Spain</li><li>Cristina Crespo, Unitat de Biofísica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, C/Casanova 143 – Planta 5 (Ala Nord), E08036 Barcelona, Spain</li><li>Carles Falcon, Unitat de Biofísica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, C/Casanova 143 – Planta 5 (Ala Nord), E08036 Barcelona, Spain</li><li>Gert Wollny, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain</li><li>Sebastià Rubí Sureda, Servei de Medicina Nuclear, Hospital Clínic, IDIBAPS, C/Villarroel 170, E08036 Barcelona, Spain</li><li>Xavier Setoain, Servei de Medicina Nuclear, Hospital Clínic, IDIBAPS, C/Villarroel 170, E08036 Barcelona, Spain</li><li>Alejandro F. Frangi, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain</li><li>Maria J. Ledesma, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain</li><li>Andrés Santos, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain</li><li>Javier Pavía, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain</li><li>Domènec Ros, Unitat de Biofísica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, C/Casanova 143 – Planta 5 (Ala Nord), E08036 Barcelona, Spain</li> </ul></li> </ul><ul class="parents"> <ul class="details"> <li>Journal <a href="http://www.springerlink.com/content/120559/">Neuroinformatics</a></li><li>Online ISSN 1559-0089</li><li>Print ISSN 1539-2791</li> </ul> </ul> en-us Copyright 2000-2026 NITRC OSI Sun, 19 Apr 2026 20:31:35 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator