http://www.nitrc.org/forum/forum.php?forum_id=4552 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>A reliable and time-saving semiautomatic spike-template-based analysis of interictal EEG-fMRI.</b></p> <p>Epilepsia. 2014 Nov 6;</p> <p>Authors: Tousseyn S, Dupont P, Robben D, Goffin K, Sunaert S, Van Paesschen W</p> <p>Abstract<br/> OBJECTIVE: A prerequisite for the implementation of interictal electroencephalography-correlated functional magnetic resonance imaging (EEG-fMRI) in the presurgical work-up for epilepsy surgery is straightforward processing. We propose a new semi-automatic method as alternative for the challenging and time-consuming visual spike identification.<br/> METHODS: Our method starts from a patient-specific spike-template, built by averaging spikes recorded on the EEG outside the scanner. Spatiotemporal cross-correlations between the template and the EEG measured during fMRI were calculated. To minimize false-positive detections, this time course of cross-correlations was binarized by means of a spike-template-specific threshold determined in healthy controls. To inform our model for statistical parametric mapping, this binarized regressor was convolved with the canonical hemodynamic response function. We validated our "template-based" method in 21 adult patients with refractory focal epilepsy with a well-defined epileptogenic zone and interictal spikes during EEG-fMRI. Sensitivity and specificity for detecting the epileptogenic zone were calculated and represented in receiver operating characteristic (ROC) curves. Our approach was compared with a previously proposed semiautomatic "topography-based" method that used the topographic amplitude distribution of spikes as a starting point for correlation-based fitting.<br/> RESULTS: Good diagnostic performance could be reached with our template-based method. The optimal area under the ROC curve was 0.77. Diagnostic performance of the topography-based method was overall low.<br/> SIGNIFICANCE: Our new template-based method is more standardized and time-saving than visual spike identification on intra-scanner EEG recordings, and preserves good diagnostic performance for detecting the epileptogenic zone.<br/> </p><p>PMID: 25377892 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Fri, 01 May 2026 7:57:06 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator