http://www.nitrc.org/forum/forum.php?forum_id=4692 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>(S)-citalopram influences amygdala modulation in healthy subjects: a randomized placebo-controlled double-blind fMRI study using dynamic causal modeling.</b></p> <p>Neuroimage. 2014 Dec 20;</p> <p>Authors: Ronald S, Marie S, Andre H, Georg K, Allan H, Gregor G, Rupert L, Christian W, Siegfried K</p> <p>Abstract<br/> Citalopram and Escitalopram are gold standard pharmaceutical treatment options for affective, anxiety and other psychiatric disorders. However, their neurophysiologic function on cortico-limbic circuits is incompletely characterized. Here we studied the neuropharmacological influence of Citalopram and Escitalopram on cortico-limbic regulatory processes by assessing the effective connectivity between orbitofrontal cortex (OFC) and amygdala using dynamic causal modeling (DCM) applied to functional MRI data. We investigated a cohort of 15 healthy subjects in a randomized, crossover, double-blind design after 10 days of Escitalopram (10mg/d (S)-citalopram), Citalopram (10mg/d (S)-citalopram and 10mg/d (R)-citalopram), or placebo. Subjects performed an emotional face discrimination task, while undergoing functional magnetic resonance imaging (fMRI) scanning at 3 Tesla. As hypothesized, the orbitofrontal cortex, in the context of the emotional face discrimination task, exhibited a down-regulatory effect on amygdala activation. This modulatory effect was significantly increased by (S)-citalopram, but not (R)-citalopram. For the first time, this study shows that (1) the differential effects of the two enantiomers (S)- and (R)-citalopram on cortico-limbic connections can be demonstrated by modeling effective connectivity methods, and (2) one of their mechanisms can be linked to an increased inhibition of amygdala activation by the orbitofrontal cortex.<br/> </p><p>PMID: 25536499 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Fri, 01 May 2026 13:09:00 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator