http://www.nitrc.org/forum/forum.php?forum_id=4749 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Optic Neuritis and the Visual Pathway: Evaluation of Neuromyelitis Optica Spectrum by Resting-State fMRI and Diffusion Tensor MRI.</b></p> <p>J Neuroimaging. 2015 Jan 15;</p> <p>Authors: Lopes FC, Alves-Leon SV, Godoy JM, de Souza Batista Scherpenhuijzen S, Fezer L, Gasparetto EL</p> <p>Abstract<br/> BACKGROUND AND PURPOSE: Optic neuritis (ON) is an acute episode of inflammation in the visual pathway (VP). It may occur as part of a demyelinating disease, which can affect white matter (WM) throughout the VP. Compensatory cortical adaptations may occur following WM damage to maintain visual integrity. Our aim was to investigate whether resting-state functional MRI (rsfMRI) can detect cortical adaptations following ON attacks and to correlate rsfMRI with diffusion tensor imaging (DTI) of WM within the VP.<br/> MATERIALS AND METHODS: Neuromyelitis optica spectrum patients were compared to healthy controls at least 6 months after ON onset. DTI and rsfMRI were performed and post-processed using FSL tools (TBSS for DTI and MELODIC for fMRI).<br/> RESULTS: Ptients had higher synchronization values than controls in the visual network (3.48 vs. 2.12, P &lt; .05). A weak trend of correlation was revealed between fMRI and structural analysis by DTI using fractional anisotropy (right side: R = -.36, P &lt; .08; left side: R = .075, P &lt; .73).<br/> CONCLUSIONS: The rsfMRI detected cortical reorganization following ON attack, but WM was considerably preserved in the posterior VP.<br/> </p><p>PMID: 25588974 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 13:37:29 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator