http://www.nitrc.org/forum/forum.php?forum_id=4888 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Differences between target and non-target probe processing - Combined evidence from fMRI, EEG and fMRI-constrained source analysis.</b></p> <p>Neuroimage. 2015 Feb 27;</p> <p>Authors: Galashan D, Fehr T, Herrmann M</p> <p>Abstract<br/> Previous studies reported heterogeneous findings in working memory tasks when examining differences between correct recognition (targets) and correct rejection (non-targets). In the present study, twenty human participants completed a delayed match-to-sample task in two separate functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) sessions. Targets and non-target items were presented at different within-trial positions. We used fMRI-constrained source analysis to investigate the spatio-temporal neuronal dynamics of probe processing. Probe type-related differences were modulated by position in the trial or by the ratio of target stimuli to non-target stimuli at different trial positions. fMRI-constrained source analysis revealed a temporal pattern of source activities starting in occipital and temporal brain regions, followed by a simultaneous engagement of parietal and frontal brain regions and a later activity of a source in pre-SMA (supplementary motor area). Source activities demonstrated a specific involvement of left fusiform gyrus in the non-target condition compared to the target condition that might be associated with mental imagination of the target stimulus during non-target probe processing. Source activities, furthermore, showed the anterior cingulate to be particularly involved in target processing compared to non-target processing before response execution and the pre-SMA before and during response execution. These brain areas appear to be activated in different stages of conflict managing operations due to a lower stimulus frequency of target trials compared to non-target trials at different target positions in the present design.<br/> </p><p>PMID: 25731996 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sat, 02 May 2026 15:45:29 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator