http://www.nitrc.org/forum/forum.php?forum_id=4929 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Reduced cortical activation in inferior frontal junction in Unverricht-Lundborg disease (EPM1) - A motor fMRI study.</b></p> <p>Epilepsy Res. 2015 Mar;111:78-84</p> <p>Authors: Könönen M, Danner N, Koskenkorva P, Kälviäinen R, Hyppönen J, Mervaala E, Karjalainen P, Vanninen R, Niskanen E</p> <p>Abstract<br/> BACKGROUND: Unverricht-Lundborg disease (EPM1) is characterized by stimulus-sensitive and action-activated myoclonus, tonic-clonic seizures and ataxia. Several disease-related alterations in cortical structure and excitability have been associated with the motor symptoms of EPM1. This study aimed to elucidate possible alterations in cortical activation related to motor performance in EPM1.<br/> METHODS: Fifteen EPM1-patients and 15 healthy volunteers matched for age and sex underwent motor functional MRI. Group differences in activations were evaluated in the primary and supplementary motor cortices and sensory cortical areas. Furthermore, in EPM1 patients, the quantitative fMRI parameters were correlated with the severity of the motor symptoms.<br/> RESULTS: The EPM1-patients exhibited decreased activation in the left inferior frontal junction (IFJ) during right hand voluntary motor task when compared with controls. In the quantitative analysis, EPM1-patients had significantly weaker activation than controls in the hand knob and supplementary motor areas (SMA). The volume of activation in M1 decreased with age and duration of disease in the patient group, whereas the volume increased with age in controls. Negative correlations were observed between fMRI parameters of SMA and disease duration or age in patients but not in controls.<br/> CONCLUSIONS: The weaker motor fMRI activation observed in EPM1 patients parallels previous neurophysiological findings and correlates with the motor symptoms of the disease. Thus, the observed decrease in IFJ activation in EPM1 patients may be associated with the difficulties in initiation or termination of motor execution, a typical clinical symptom in EPM1. The fMRI findings reflect the progressive nature of this disease.<br/> </p><p>PMID: 25769376 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Fri, 01 May 2026 21:43:02 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator