http://www.nitrc.org/forum/forum.php?forum_id=5118 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Long-and short-range functional connectivity density alteration in non-alcoholic cirrhotic patients one month after liver transplantation: A resting-state fMRI study.</b></p> <p>Brain Res. 2015 Apr 29;</p> <p>Authors: Zhang XD, Cheng Y, Poon CS, Qi RF, Xu Q, Chen HJ, Kong X, Lu GM, Shen W, Zhang LJ</p> <p>Abstract<br/> PURPOSE: To longitudinally evaluate long- and short-range functional connectivity density (FCD) alteration in cirrhotic patients one month after liver transplantation (LT) and their correlation with cognitive changes by using resting-state functional magnetic resonance imaging (rs-fMRI).<br/> METHODS: Twenty seven candidates awaiting LT and 24 age-, gender-, and education-matched healthy controls (HCs) were studied. All 27 patients and HCs performed rs-fMRI examinations. Of 27 cirrhotic patients, 13 patients received LT underwent the repeated rs-fMRI examinations one month after LT. Laboratory and psychometric tests were carried out. The long- and short-range FCD maps derived from degree centrality calculation were compared. Correlations between FCD alteration and laboratory/psychometric changes were evaluated as well.<br/> RESULTS: In cirrhotic patients, most of the brain areas with altered long- and short-range FCD could reverse one month after LT, which was accompanied with cognitive and liver functional improvement. The reduced long-range FCD in right posterior cingulate cortex (PCC) and Left middle frontal gyrus (MFG), and reduced short-range FCD in right precuneus (PCu) persisted in the early period after LT. In addition, one month after LT, the post-LT group showed reduced long-range FCD in right rectus gyrus (REC) and left medial prefrontal cortex (MPFC), and reduced short-range FCD in left middle temporal gyrus (MTG), when compared with the pre-LT group. We found Δdigital symbol test (ΔDST) score positively correlated with long-rangeΔFCD in right precentral gyrus (preCG) (r=0.72, P&lt;0.01) and right supplementary motor area (SMA) (r=0.59, P&lt;0.05).<br/> CONCLUSION: LT results in favorable effect on cognitive function in cirrhotic patient, which can be reflected by FCD alteration. However, persistence of PCC/PCu functional connectivity disturbance one month after LT indicates complete cognitive function restoration may need a longer time.<br/> </p><p>PMID: 25935693 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 16:25:52 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator