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  <title>NITRC News Group Forum: diagnosis-of-posttraumatic-stress-disorder--ptsd--based-on-correlations-of-prewhitened-fmri-data--outcomes-and-areas-involved.</title>
  <link>http://www.nitrc.org/forum/forum.php?forum_id=5265</link>
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	&lt;table border=&quot;0&quot; width=&quot;100%&quot;&gt;&lt;tr&gt;&lt;td align=&quot;left&quot;/&gt;&lt;td align=&quot;right&quot;&gt;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;amp;cmd=Link&amp;amp;LinkName=pubmed_pubmed&amp;amp;from_uid=26070898&quot;&gt;Related Articles&lt;/a&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;
        &lt;p&gt;&lt;b&gt;Diagnosis of posttraumatic stress disorder (PTSD) based on correlations of prewhitened fMRI data: outcomes and areas involved.&lt;/b&gt;&lt;/p&gt;          
        &lt;p&gt;Exp Brain Res. 2015 Jun 13;&lt;/p&gt;
        &lt;p&gt;Authors:  Christova P, James LM, Engdahl BE, Lewis SM, Georgopoulos AP&lt;/p&gt;
        &lt;p&gt;Abstract&lt;br/&gt;
        Successful diagnosis of PTSD has been achieved using neural correlations from prewhitened magnetoencephalographic (MEG) time series (Georgopoulos et al. in J Neural Eng 7:16011, 2010. doi:10.1088/1741-2560/7/1/016011; James et al. 2015). Here, we show that highly successful classification of PTSD and control subjects can be obtained using neural correlations from prewhitened resting-state fMRI data. All but one PTSD (14/15; sensitivity = 93.3 %) and all but one control (20/21; specificity = 95.2 %) subjects were correctly classified using 15 out of 2701 possible correlations between 74 brain areas. In contrast, correlations of the same but non-prewhitened data yielded chance-level classifications. We conclude that, if properly processed, fMRI has the prospect of aiding significantly in PTSD diagnosis. Twenty-five brain areas were most prominently involved in correct subject classification, including areas from all cortical lobes and the left pallidum.&lt;br/&gt;
        &lt;/p&gt;&lt;p&gt;PMID: 26070898 [PubMed - as supplied by publisher]&lt;/p&gt;
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