http://www.nitrc.org/forum/forum.php?forum_id=5292 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=26094886">Related Articles</a></td></tr></table> <p><b>Spatial working memory impairment in primary onset middle-age type 2 diabetes mellitus: An ethology and BOLD-fMRI study.</b></p> <p>J Magn Reson Imaging. 2015 Jun 11;</p> <p>Authors: Huang RR, Jia BH, Xie L, Ma SH, Yin JJ, Sun ZB, Le HB, Xu WC, Huang JZ, Luo DX</p> <p>Abstract<br/> PURPOSE: To explore mild cognitive dysfunction and/or spatial working memory impairment in patients with primary onset middle-age type 2 diabetes mellitus (T2DM] using ethology (behavior tests) and blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI).<br/> MATERIALS AND METHODS: Eighteen primary onset T2DM patients and 18 matched subjects with normal blood glucose levels were all tested using the Montreal cognitive assessment scale test, the Wechsler Memory Scale Chinese-revised test, and scanned using BOLD-fMRI (1.5T, EPI sequence) while performing the n-back task to find the activation intensity of some cognition-related areas.<br/> RESULTS: The ethology results showed that T2DM patients had a mild cognitive impairment and memory dysfunction (P &lt; 0.05). The fMRI scan identified a neural network consisting of bilateral dorsolateral prefrontal cortex (DLPFC), bilateral premotor area (PreMA), bilateral parietal lobe (PA), and anterior cingulate cortex (ACC) / supplementary motor area (SMA) that was activated during the n-back task, with right hemisphere dominance. However, only the right PA and ACC/SMA showed a load effect via quantitative analysis in the T2DM group; the activation intensity of most working memory-related brain areas for the T2DM group were lower than for the control group under three memory loads. Furthermore, we found that the activation intensity of some cognition-related areas, including the right insular lobe, left caudate nucleus, and bilateral hippocampus/parahippocampal gyrus were lower than the control group under the memory loads.<br/> CONCLUSION: Diabetes-related brain damage of primary onset middle-age T2DM patients with right DLPFC-posterior parietal lobe and parahippocampal gyrus default network causes impairment of spatial working memory and mild cognitive dysfunction.J. Magn. Reson. Imaging 2015.<br/> </p><p>PMID: 26094886 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sat, 02 May 2026 15:14:30 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator