http://www.nitrc.org/forum/forum.php?forum_id=5371 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>What letters can "learn" from Arabic digits - fMRI-controlled single case therapy study of peripheral agraphia.</b></p> <p>Brain Lang. 2015 Jul 14;149:13-26</p> <p>Authors: Jung S, Halm K, Huber W, Willmes K, Klein E</p> <p>Abstract<br/> Research on (hand-)writing has revealed that Exner's area subserves transferring linguistic impulses into writing programmes. We report on a patient with a lesion affecting Broca's and Exner's area suffering from severe peripheral agraphia for letters but not for Arabic digits. Analogous to semantic (magnitude) information in numbers, we developed a specifically tailored writing training: additional mental imagery based semantic information was attached to letters. The training resulted in significant improvements. Imaging data revealed stronger fronto-parietal network activity including perilesional activation around Exner's area and precuneus for writing letters to dictation than for writing letters corresponding to their mental image expressions. Follow-up testing showed not only stable training effects but also an activation shift into the left angular gyrus. Results document neuronal correlates of a successful intervention by attaching additional meanings to letters in order to retrieve their grapho-motor patterns. These findings contribute to understanding the impact of Exner's area.<br/> </p><p>PMID: 26186229 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 19:48:18 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator