http://www.nitrc.org/forum/forum.php?forum_id=5686 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Bimanual non-congruent actions in motor neglect syndrome: a combined behavioral/fMRI study.</b></p> <p>Front Hum Neurosci. 2015;9:541</p> <p>Authors: Garbarini F, Turella L, Rabuffetti M, Cantagallo A, Piedimonte A, Fainardi E, Berti A, Fadiga L</p> <p>Abstract<br/> In Motor Neglect (MN) syndrome, a specific impairment in non-congruent bimanual movements has been described. In the present case-control study, we investigated the neuro-functional correlates of this behavioral deficit. Two right-brain-damaged (RBD) patients, one with (MN+) and one without (MN-) MN, were evaluated by means of functional Magnetic Resonance Imaging (fMRI) in a bimanual Circles-Lines (CL) paradigm. Patients were requested to perform right-hand movements (lines-drawing) and, simultaneously, congruent (lines-drawing) or non-congruent (circles-drawing) left-hand movements. In the behavioral task, MN- patient showed a bimanual-coupling-effect, while MN+ patient did not. The fMRI study showed that in MN-, a fronto-parietal network, mainly involving the pre-supplementary motor area (pre-SMA) and the posterior parietal cortex (PPC), was significantly more active in non-congruent than in congruent conditions, as previously shown in healthy subjects. On the contrary, MN+ patient showed an opposite pattern of activation both in pre-SMA and in PPC. Within this fronto-parietal network, the pre-SMA is supposed to exert an inhibitory influence on the default coupling of homologous muscles, thus allowing the execution of non-congruent movements. In MN syndrome, the described abnormal pre-SMA activity supports the hypothesis that a failure to inhibit ipsilesional motor programs might determine a specific impairment of non-congruent movements.<br/> </p><p>PMID: 26500520 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Mon, 04 May 2026 0:34:42 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator