http://www.nitrc.org/forum/forum.php?forum_id=5715 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Altered cerebellar-amygdala connectivity in violent offenders: a resting-state fMRI study.</b></p> <p>Neurosci Lett. 2015 Oct 30;</p> <p>Authors: Leutgeb V, Wabnegger A, Leitner M, Zussner T, Scharmüller W, Klug D, Schienle A</p> <p>Abstract<br/> It has repeatedly been reported, that there are differences in grey matter volume (GMV) between violent offenders and non-violent controls. However, it remains unclear, if structural brain abnormalities influence resting-state functional connectivity (RS-fc) between brain regions. Therefore, in the present investigation, 31 male high-risk violent prisoners were compared to 30 non-criminal controls with respect to RS-fc between brain areas. Seed regions for resting-state analysis were selected based on GMV differences between the two groups. Overall, inmates had more GMV in the cerebellum than controls and revealed higher RS-fc between the cerebellum and the amygdala. In contrast, controls relative to prisoners showed higher RS-fc between the cerebellum and the orbitofrontal cortex (OFC). In addition, controls showed more GMV in the dorsolateral prefrontal cortex (DLPFC). Inmates relative to controls had higher RS-fc within the DLPFC. Results are discussed with respect to cerebellar contributions to a brain network underlying moral behavior and violence. Enhanced cerebellar-amygdala connectivity in violent offenders might reflect alterations in the processing of moral emotions. Heightened functional connectivity between cerebellar hemispheres and the OFC in controls could be a correlate of enhanced emotion regulation capacities. Higher functional intra-DLPFC connectivity in violent offenders might represent an effort to regulate emotions.<br/> </p><p>PMID: 26523791 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Mon, 04 May 2026 2:28:42 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator