http://www.nitrc.org/forum/forum.php?forum_id=5774 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>The role of Brain Derived Neurotrophic Factor in learned fear processing: an awake rat fMRI study.</b></p> <p>Genes Brain Behav. 2015 Nov 20;</p> <p>Authors: Harris AP, Lennen RJ, Brydges NM, Jansen MA, Pernet CR, Whalley HC, Marshall I, Baker S, Basso AM, Day M, Holmes MC, Hall J</p> <p>Abstract<br/> Brain-derived neurotrophic factor (BDNF) signaling is implicated in the aetiology of many psychiatric disorders associated with altered emotional processing. Altered peripheral (plasma) BDNF levels have been proposed as a biomarker for neuropsychiatric disease risk in humans. However the relationship between peripheral and central BDNF levels and emotional brain activation is unknown. We used heterozygous BDNF knockdown rats (BDNF(+/-) ) to examine the effects of genetic variation in the BDNF gene on peripheral and central BDNF levels and emotional brain activation as assessed by awake fMRI. BDNF(+/-) and control rats were trained to associate a flashing light (conditioned stimulus; CS) with foot-shock, and brain activation in response to the CS was measured 24h later in awake rats using fMRI. Central and peripheral BDNF levels were decreased in BDNF(+/-) rats compared to control rats. Activation of fear circuitry (amygdala, periaqueductal gray, granular insular) was seen in control animals, however activation of this circuitry was absent in BDNF(+/-) animals. Behavioral experiments confirmed impaired conditioned fear responses in BDNF(+/-) rats, despite intact innate fear responses. These data confirm a positive correlation (r = 0.86, 95% CI [0.55, 0.96]; P = 0.0004) between peripheral and central BDNF levels and indicate a functional relationship between BDNF levels and emotional brain activation as assessed by fMRI. The results demonstrate the use of rodent fMRI as a sensitive tool for measuring brain function in preclinical translational studies using genetically modified rats and support the use of peripheral BDNF as a biomarker of central affective processing.<br/> </p><p>PMID: 26586578 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Mon, 04 May 2026 4:03:10 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator