http://www.nitrc.org/forum/forum.php?forum_id=5805 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>A Systematic Review and Meta-Analysis of the Functional MRI Investigation of Motor Neuron Disease.</b></p> <p>Front Neurol. 2015;6:246</p> <p>Authors: Shen D, Cui L, Cui B, Fang J, Li D, Ma J</p> <p>Abstract<br/> BACKGROUND: To assess the use of functional magnetic resonance imaging (fMRI) in motor neuron disease (MND), a systematic review and voxelwise meta-analysis of studies comparing brain activity in patients with MND and in healthy controls was conducted to identify common findings across studies.<br/> METHODS: A search for related papers published in English and Chinese was performed in Ovid Medline, Pubmed, and Embase database. Voxelwise meta-analysis was performed using signed differential mapping.<br/> RESULTS: The findings from 55 fMRI studies on MND were tabulated, and some common findings were discussed in further details.<br/> CONCLUSION: These findings are preliminary, sometimes even contradictory, and do not allow a complete understanding of the functional alterations in MND. However, we documented reliable findings that MND is not confined to the motor system, but is a multisystem disorder involving extra-motor cortex areas, causing cognitive dysfunction and deficits in socioemotional and sensory processing pathways.<br/> </p><p>PMID: 26635722 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 22:26:03 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator