http://www.nitrc.org/forum/forum.php?forum_id=5878 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Single stimulus fMRI produces a neural individual difference measure for Autism Spectrum Disorder.</b></p> <p>Clin Psychol Sci. 2015 May 1;3(3):422-432</p> <p>Authors: Lu J, Kishida K, De Asis Cruz J, Lohrenz T, Deering DT, Beauchamp M, Montague PR</p> <p>Abstract<br/> Functional magnetic resonance imaging typically makes inferences about neural substrates of cognitive phenomena at the group level. We report the use of a single-stimulus BOLD response in the cingulate cortex that differentiates individual children with autism spectrum disorder from matched typically developing control children with sensitivity and specificity of 63.6% and 73.7% respectively. The approach consists of passive viewing of 'self' and 'other' faces from which an individual difference measure is derived from the BOLD response to the first 'self' image only; the method, penalized logistic regression, requires no averaging over stimulus presentations or individuals. These findings show that single-stimulus fMRI responses can be extracted from individual subjects and used profitably as a neural individual difference measure. The result suggests that single-stimulus fMRI can be developed to produce quantitative neural biomarkers for other developmental disorders and may even be useful in the rapid typing of cognition in healthy individuals.<br/> </p><p>PMID: 26722624 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 23:46:16 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator