http://www.nitrc.org/forum/forum.php?forum_id=5909 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.</b></p> <p>J Affect Disord. 2015 Dec 31;193:175-184</p> <p>Authors: Armstrong CC, Moody TD, Feusner JD, McCracken JT, Chang S, Levitt JG, Piacentini JC, O'Neill J</p> <p>Abstract<br/> BACKGROUND: fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD.<br/> METHODS: Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD.<br/> RESULTS: As in adults, the global metric small-worldness was significantly (P&lt;0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P&lt;0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P&lt;0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P&lt;0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites.<br/> LIMITATIONS: Relatively large node size; relatively small sample size, comorbidities in some patients.<br/> CONCLUSIONS: Pediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.<br/> </p><p>PMID: 26773910 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Mon, 04 May 2026 13:03:08 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator