http://www.nitrc.org/forum/forum.php?forum_id=5981 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>fMRI activation in the middle frontal gyrus as an indicator of hemispheric dominance for language in brain tumor patients: a comparison with Broca's area.</b></p> <p>Neuroradiology. 2016 Feb 5;</p> <p>Authors: Dong JW, Brennan NM, Izzo G, Peck KK, Holodny AI</p> <p>Abstract<br/> INTRODUCTION: Functional MRI (fMRI) can assess language lateralization in brain tumor patients; however, this can be limited if the primary language area-Broca's area (BA)-is affected by the tumor. We hypothesized that the middle frontal gyrus (MFG) can be used as a clinical indicator of hemispheric dominance for language during presurgical workup.<br/> METHODS: Fifty-two right-handed subjects with solitary left-hemispheric primary brain tumors were retrospectively studied. Subjects performed a verbal fluency task during fMRI. The MFG was compared to BA for fMRI voxel activation, language laterality index (LI), and the effect of tumor grade on the LI.<br/> RESULTS: Language fMRI (verbal fluency) activated more voxels in MFG than in BA (MFG = 315, BA = 216, p &lt; 0.001). Voxel activations in the left-hemispheric MFG and BA were positively correlated (r = 0.69, p &lt; 0.001). Mean LI in the MFG was comparable to that in BA (MFG = 0.48, BA = 0.39, p = 0.06). LIs in MFG and BA were positively correlated (r = 0.62, p &lt; 0.001). Subjects with high-grade tumors demonstrate lower language lateralization than those with low-grade tumors in both BA and MFG (p = 0.02, p = 0.02, respectively).<br/> CONCLUSION: MFG is comparable to BA in its ability to indicate hemispheric dominance for language using a measure of verbal fluency and may be an adjunct measure in the clinical determination of language laterality for presurgical planning.<br/> </p><p>PMID: 26847705 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Mon, 04 May 2026 4:44:19 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator