http://www.nitrc.org/forum/forum.php?forum_id=6404 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study.</b></p> <p>Pain. 2016 May 30;</p> <p>Authors: Schrepf A, Harper DE, Harte SE, Wang H, Ichesco E, Hampson JP, Zubieta JK, Clauw DJ, Harris RE</p> <p>Abstract<br/> Endogenous opioid system dysfunction potentially contributes to chronic pain in fibromyalgia but it is unknown if this dysfunction is related to established neurobiological markers of hyperalgesia. We previously reported that µ-opioid receptor (MOR) availability was reduced in fibromyalgia patients as compared to healthy controls in several pain-processing brain regions. In the present study, we compared pain-evoked functional magnetic resonance imaging to endogenous MOR binding and clinical pain ratings in female opioid-naïve fibromyalgia patients (n=18) using whole-brain analyses and regions of interest (ROI) from our previous research. Within anti-nociceptive brain regions, including the dorsolateral prefrontal cortex (r = .81, p &lt; .001) and multiple regions of the anterior cingulate cortex (all r &gt; 0.67; all p &lt; .02), reduced MOR availability was associated with decreased pain-evoked neural activity. Additionally, reduced MOR availability was associated with lower brain activation in the nucleus accumbens (r = 0.47, p = .050). In many of these regions pain-evoked activity and MOR binding potential were also associated with lower clinical affective pain ratings. These findings are the first to link endogenous opioid system tone to regional pain-evoked brain activity in a clinical pain population. Our data suggests that dysregulation of the endogenous opioid system in fibromyalgia could lead to less excitation in antinociceptive brain regions by incoming noxious stimulation, resulting in the hyperalgesia and allodynia commonly observed in this population. We propose a conceptual model of affective pain dysregulation in fibromyalgia.<br/> </p><p>PMID: 27420606 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Tue, 05 May 2026 0:26:25 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator