http://www.nitrc.org/forum/forum.php?forum_id=6487 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Review of thalamocortical resting-state fMRI studies in schizophrenia.</b></p> <p>Schizophr Res. 2016 Aug 13;</p> <p>Authors: Giraldo-Chica M, Woodward ND</p> <p>Abstract<br/> Brain circuitry underlying cognition, emotion, and perception is abnormal in schizophrenia. There is considerable evidence that the neuropathology of schizophrenia includes the thalamus, a key hub of cortical-subcortical circuitry and an important regulator of cortical activity. However, the thalamus is a heterogeneous structure composed of several nuclei with distinct inputs and cortical connections. Limitations of conventional neuroimaging methods and conflicting findings from post-mortem investigations have made it difficult to determine if thalamic pathology in schizophrenia is widespread or limited to specific thalamocortical circuits. Resting-state fMRI has proven invaluable for understanding the large-scale functional organization of the brain and investigating neural circuitry relevant to psychiatric disorders. This article summarizes resting-state fMRI investigations of thalamocortical functional connectivity in schizophrenia. Particular attention is paid to the course, diagnostic specificity, and clinical correlates of thalamocortical network dysfunction.<br/> </p><p>PMID: 27531067 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Tue, 05 May 2026 3:12:07 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator