http://www.nitrc.org/forum/forum.php?forum_id=7060 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Increased insular connectivity with emotional regions in primary insomnia patients: a resting-state fMRI study.</b></p> <p>Eur Radiol. 2017 Jan 31;:</p> <p>Authors: Wang T, Yan J, Li S, Zhan W, Ma X, Xia L, Li M, Lin C, Tian J, Li C, Jiang G</p> <p>Abstract<br/> OBJECTIVE: To explore the abnormal connectivity patterns between the insular and the voxels of the brain in primary insomnia (PI) with insular-based functional connectivity (FC).<br/> METHODS: With the resting-state fMRI data acquired from 57 PI patients and 46 healthy controls, a two-sample t test was performed on individual FC correlation maps from two groups. The person correlation analysis was used to evaluate the relationship between the abnormal FC and clinical features.<br/> RESULTS: PI patients show enhanced connectivity between the left insula with the right anterior cingulate cortex (p &lt; 0.05 and p &lt; 0.001, AlphaSim-corrected), right frontal sup orb, bilateral thalamus and left precuneus,as well as decreased connectivity with the left middle temporal gyrus and right fusiform (p &lt; 0.05, AlphaSim-corrected). Correlation analysis indicated the enhanced connectivities in the PI patients have significant negative correlations with Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS)scores. In addition, the decreased functional connectivities showed positive correlations with SDS and SAS scores.<br/> CONCLUSION: Our study showed the increased connectivity regions with insula were mainly in the emotional circle and decreased connectivity was in cognitive-related regions. These provide additional evidence from functional integration view to understand the possible underlying neural- mechanisms of PI.<br/> KEY POINTS: • The aberrant insular-based connectivity pattern of PI patients was detected. • Regions showing increased connectivity with left insular were mainly in emotional circle. • Significant correlations between changed FC and SDS and SAS score were found.<br/> </p><p>PMID: 28144739 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Wed, 06 May 2026 11:47:06 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator