http://www.nitrc.org/forum/forum.php?forum_id=7394 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=28446211">Related Articles</a></td></tr></table> <p><b>Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report.</b></p> <p>BMC Res Notes. 2017 Apr 26;10(1):165</p> <p>Authors: Edes AE, Kozak LR, Magyar M, Zsombok T, Kokonyei G, Bagdy G, Juhasz G</p> <p>Abstract<br/> BACKGROUND: Although migraine is one of the most investigated neurologic disorders, we do not have a perfect neuroimaging biomarker for its pathophysiology. One option to improve our knowledge is to study resting-state functional connectivity in and out of headache pain. However, our understanding of the functional connectivity changes during spontaneous migraine attack is partial and incomplete.<br/> CASE PRESENTATION: Using resting-state functional magnetic resonance imaging we assessed a 24-year old woman affected by migraine without aura at two different times: during a spontaneous migraine attack and in interictal phase. Seed-to-voxel whole brain analysis was carried out using the posterior cingulate cortex as a seed, representing the default mode network (DMN). Our results showed decreased intrinsic connectivity within core regions of the DMN with an exception of a subsystem including the dorsal medial and superior frontal gyri, and the mid-temporal gyrus which is responsible for pain interpretation and control. In addition, increased connectivity between the DMN and pain and specific migraine-related areas, such as the pons and hypothalamus, developed during the spontaneous migraine attack.<br/> CONCLUSION: Our preliminary results provide further support for the hypothesis that alterations of the DMN functional connectivity during migraine headache may lead to maladaptive top-down modulation of migraine pain-related areas which might be a specific biomarker for migraine.<br/> </p><p>PMID: 28446211 [PubMed - in process]</p> en-us Copyright 2000-2026 NITRC OSI Wed, 06 May 2026 16:00:53 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator