http://www.nitrc.org/forum/forum.php?forum_id=7430 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors.</b></p> <p>J Cereb Blood Flow Metab. 2017 Jan 01;:271678X17707398</p> <p>Authors: Pak RW, Hadjiabadi DH, Senarathna J, Agarwal S, Thakor NV, Pillai JJ, Pathak AP</p> <p>Abstract<br/> Functional magnetic resonance imaging (fMRI) serves as a critical tool for presurgical mapping of eloquent cortex and changes in neurological function in patients diagnosed with brain tumors. However, the blood-oxygen-level-dependent (BOLD) contrast mechanism underlying fMRI assumes that neurovascular coupling remains intact during brain tumor progression, and that measured changes in cerebral blood flow (CBF) are correlated with neuronal function. Recent preclinical and clinical studies have demonstrated that even low-grade brain tumors can exhibit neurovascular uncoupling (NVU), which can confound interpretation of fMRI data. Therefore, to avoid neurosurgical complications, it is crucial to understand the biophysical basis of NVU and its impact on fMRI. Here we review the physiology of the neurovascular unit, how it is remodeled, and functionally altered by brain cancer cells. We first discuss the latest findings about the components of the neurovascular unit. Next, we synthesize results from preclinical and clinical studies to illustrate how brain tumor induced NVU affects fMRI data interpretation. We examine advances in functional imaging methods that permit the clinical evaluation of brain tumors with NVU. Finally, we discuss how the suppression of anomalous tumor blood vessel formation with antiangiogenic therapies can "normalize" the brain tumor vasculature, and potentially restore neurovascular coupling.<br/> </p><p>PMID: 28492341 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Wed, 06 May 2026 16:39:37 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator