http://www.nitrc.org/forum/forum.php?forum_id=7608 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Effects of taurine on resting-state fMRI activity in spontaneously hypertensive rats.</b></p> <p>PLoS One. 2017;12(7):e0181122</p> <p>Authors: Chen VC, Hsu TC, Chen LJ, Chou HC, Weng JC, Tzang BS</p> <p>Abstract<br/> Attention deficit hyperactivity disorder (ADHD) is a global behavior illness among children and adults. To investigate the effects of taurine on resting-state fMRI activity in ADHD, a spontaneously hypertensive rat (SHR) animal model was adopted. Significantly decreased serum C-reactive protein (CRP) was detected in rats of Wistar Kyoto (WKY) high-taurine group and significantly decreased interleukin (IL)-1β and CRP were detected in rats of SHR low-taurine and high-taurine groups. Moreover, significantly higher horizontal locomotion was detected in rats of WKY low-taurine and SHR low-taurine groups than in those of controls. In contrast, significantly lower horizontal locomotion was detected in rats of the SHR high-taurine group than in those of the SHR control group. Additionally, significantly lower functional connectivity (FC) and mean amplitude of low-frequency fluctuation (mALFF) in the bilateral hippocampus in rats of WKY high-taurine and SHR high-taurine groups was detected. Notably, the mALFF in rats of the SHR low-taurine and high-taurine groups was significantly lower than in those of the SHR control group. These findings suggest that the administration of a high-dose taurine probably improves hyperactive behavior in SHR rats by ameliorating the inflammatory cytokines and modulating brain functional signals in SHR rats.<br/> </p><p>PMID: 28700674 [PubMed - in process]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 8:04:59 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator