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  <title>NITRC News Group Forum: multivariate-bayesian-decoding-of-single-trial-event-related-fmri-responses-for-memory-retrieval-of-voluntary-actions.</title>
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        &lt;p&gt;&lt;b&gt;Multivariate Bayesian decoding of single-trial event-related fMRI responses for memory retrieval of voluntary actions.&lt;/b&gt;&lt;/p&gt;          
        &lt;p&gt;PLoS One. 2017;12(8):e0182657&lt;/p&gt;
        &lt;p&gt;Authors:  Lee D, Yun S, Jang C, Park HJ&lt;/p&gt;
        &lt;p&gt;Abstract&lt;br/&gt;
        This study proposes a method for classifying event-related fMRI responses in a specialized setting of many known but few unknown stimuli presented in a rapid event-related design. Compared to block design fMRI signals, classification of the response to a single or a few stimulus trial(s) is not a trivial problem due to contamination by preceding events as well as the low signal-to-noise ratio. To overcome such problems, we proposed a single trial-based classification method of rapid event-related fMRI signals utilizing sparse multivariate Bayesian decoding of spatio-temporal fMRI responses. We applied the proposed method to classification of memory retrieval processes for two different classes of episodic memories: a voluntarily conducted experience and a passive experience induced by watching a video of others' actions. A cross-validation showed higher classification performance of the proposed method compared to that of a support vector machine or of a classifier based on the general linear model. Evaluation of classification performances for one, two, and three stimuli from the same class and a correlation analysis between classification accuracy and target stimulus positions among trials suggest that presenting two target stimuli at longer inter-stimulus intervals is optimal in the design of classification experiments to identify the target stimuli. The proposed method for decoding subject-specific memory retrieval of voluntary behavior using fMRI would be useful in forensic applications in a natural environment, where many known trials can be extracted from a simulation of everyday tasks and few target stimuli from a crime scene.&lt;br/&gt;
        &lt;/p&gt;&lt;p&gt;PMID: 28777830 [PubMed - in process]&lt;/p&gt;
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