http://www.nitrc.org/forum/forum.php?forum_id=7760 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=28844505">Related Articles</a></td></tr></table> <p><b>Using resting-state fMRI to assess the effect of aerobic exercise on functional connectivity of the DLPFC in older overweight adults.</b></p> <p>Brain Cogn. 2017 Aug 23;:</p> <p>Authors: Prehn K, Lesemann A, Krey G, Witte AV, Köbe T, Grittner U, Flöel A</p> <p>Abstract<br/> Cardiovascular fitness is thought to exert beneficial effects on brain function and might delay the onset of cognitive decline. Empirical evidence of exercise-induced cognitive enhancement, however, has not been conclusive, possibly due to short intervention times in clinical trials. Resting-state functional connectivity (RSFC) has been proposed asan early indicator for intervention-induced changes. Here, we conducted a study in which healthy older overweight subjects took either part in a moderate aerobic exercise program over 6months (AE group; n=11) or control condition of non-aerobic stretching and toning (NAE group; n=18). While cognitive and gray matter volume changes were rather small (i.e., appeared only in certain sub-scores without Bonferroni correction for multiple comparisons or using small volume correction), we found significantly increased RSFC after training between dorsolateral prefrontal cortex and superior parietal gyrus/precuneus in the AE compared to the NAE group. This intervention study demonstrates an exercise-induced modulation of RSFC between key structures of the executive control and default mode networks, which might mediate an interaction between task-positive and task-negative brain activation required for task switching. Results further emphasize the value of RSFC asa sensitive biomarker for detecting early intervention-related cognitive improvements in clinical trials.<br/> </p><p>PMID: 28844505 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 0:03:53 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator