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  <title>NITRC News Group Forum: icn_atlas--automated-description-and-quantification-of-functional-mri-activation-patterns-in-the-framework-of-intrinsic-connectivity-networks.</title>
  <link>http://www.nitrc.org/forum/forum.php?forum_id=7817</link>
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	&lt;table border=&quot;0&quot; width=&quot;100%&quot;&gt;&lt;tr&gt;&lt;td align=&quot;left&quot;/&gt;&lt;td align=&quot;right&quot;&gt;&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;amp;cmd=Link&amp;amp;LinkName=pubmed_pubmed&amp;amp;from_uid=28899742&quot;&gt;Related Articles&lt;/a&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;
        &lt;p&gt;&lt;b&gt;ICN_Atlas: Automated description and quantification of functional MRI activation patterns in the framework of intrinsic connectivity networks.&lt;/b&gt;&lt;/p&gt;          
        &lt;p&gt;Neuroimage. 2017 Sep 09;:&lt;/p&gt;
        &lt;p&gt;Authors:  Kozák LR, van Graan LA, Chaudhary UJ, Szabó Á, Lemieux L&lt;/p&gt;
        &lt;p&gt;Abstract&lt;br/&gt;
        Generally, the interpretation of functional MRI (fMRI) activation maps continues to rely on assessing their relationship to anatomical structures, mostly in a qualitative and often subjective way. Recently, the existence of persistent and stable brain networks of functional nature has been revealed; in particular these so-called intrinsic connectivity networks (ICNs) appear to link patterns of resting state and task-related state connectivity. These networks provide an opportunity of functionally-derived description and interpretation of fMRI maps, that may be especially important in cases where the maps are predominantly task-unrelated, such as studies of spontaneous brain activity e.g. in the case of seizure-related fMRI maps in epilepsy patients or sleep states. Here we present a new toolbox (ICN_Atlas) aimed at facilitating the interpretation of fMRI data in the context of ICN. More specifically, the new methodology was designed to describe fMRI maps in function-oriented, objective and quantitative way using a set of 15 metrics conceived to quantify the degree of 'engagement' of ICNs for any given fMRI-derived statistical map of interest. We demonstrate that the proposed framework provides a highly reliable quantification of fMRI activation maps using a publicly available longitudinal (test-retest) resting-state fMRI dataset. The utility of the ICN_Atlas is also illustrated on a parametric task-modulation fMRI dataset, and on a dataset of a patient who had repeated seizures during resting-state fMRI, confirmed on simultaneously recorded EEG. The proposed ICN_Atlas framework will be made freely available for download at https://www.nitrc.org and at http://incatlas.com for researchers to use in their fMRI investigations.&lt;br/&gt;
        &lt;/p&gt;&lt;p&gt;PMID: 28899742 [PubMed - as supplied by publisher]&lt;/p&gt;
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