http://www.nitrc.org/forum/forum.php?forum_id=7992 <h3 class="a-plus-plus">Abstract</h3> <p class="a-plus-plus">The larval brain of the fruit fly <em class="a-plus-plus">Drosophila melanogaster</em> is a small, tractable model system for neuroscience. Genes for fluorescent marker proteins can be expressed in defined, spatially restricted neuron populations. Here, we introduce the methods for 1) generating a standard template of the larval central nervous system (CNS), 2) spatial mapping of expression patterns from different larvae into a reference space defined by the standard template. We provide a manually annotated gold standard that serves for evaluation of the registration framework involved in template generation and mapping. A method for registration quality assessment enables the automatic detection of registration errors, and a semi-automatic registration method allows one to correct registrations, which is a prerequisite for a high-quality, curated database of expression patterns. All computational methods are available within the <em class="a-plus-plus">larvalign</em> software package: <a href="https://github.com/larvalign/larvalign/releases/tag/v1.0" class="a-plus-plus">https://github.com/larvalign/larvalign/releases/tag/v1.0</a> </p> en-us Copyright 2000-2026 NITRC OSI Mon, 20 Apr 2026 3:03:19 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator