http://www.nitrc.org/forum/forum.php?forum_id=8000 <table border="0" width="100%"><tr><td align="left"/></tr></table> <p><b>Heterogenous migraine aura symptoms correlate with visual cortex fMRI responses.</b></p> <p>Ann Neurol. 2017 Nov 11;:</p> <p>Authors: Arngrim N, Hougaard A, Ahmadi K, Vestergaard MB, Schytz HW, Amin FM, Larsson HBW, Olesen J, Hoffmann MB, Ashina M</p> <p>Abstract<br/> OBJECTIVE: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained.<br/> METHODS: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham or physical exercise and photostimulation. The blood oxygenation level-dependent (BOLD) functional MRI (fMRI) signal response to visual stimulation was measured in retinotopic mapping defined visual cortex area V1 - V4.<br/> RESULTS: We found reduced BOLD response in patients reporting scotoma and increased response in patients who only experienced positive symptoms. Furthermore, patients with bilateral visual symptoms had corresponding bi-hemispherical changes in BOLD response.<br/> INTERPRETATION: These findings suggest that different aura symptoms reflect different types of cerebral dysfunction, which correspond to specific changes in BOLD signal reactivity. Furthermore, we provide evidence of bilateral CSD recorded by fMRI during bilateral aura symptoms. This article is protected by copyright. All rights reserved.<br/> </p><p>PMID: 29130510 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 03 May 2026 6:08:03 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator