http://www.nitrc.org/forum/forum.php?forum_id=8235 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=29398365">Related Articles</a></td></tr></table> <p><b>The Basal Forebrain Regulates Global Resting-State fMRI Fluctuations.</b></p> <p>Neuron. 2018 Jan 31;:</p> <p>Authors: Turchi J, Chang C, Ye FQ, Russ BE, Yu DK, Cortes CR, Monosov IE, Duyn JH, Leopold DA</p> <p>Abstract<br/> Patterns of spontaneous brain activity, typically measured in humans at rest with fMRI, are used routinely to assess the brain's functional organization. The mechanisms that generate and coordinate the underlying neural fluctuations are largely unknown. Here we investigate the hypothesis that the nucleus basalis of Meynert (NBM), the principal source of widespread cholinergic and GABAergic projections to the cortex, contributes critically to such activity. We reversibly inactivated two distinct sites of the NBM in macaques while measuring fMRI activity across the brain. We found that inactivation led to strong, regionalized suppression of shared or "global" signal components of cortical fluctuations ipsilateral to the injection. At the same time, the commonly studied resting-state networks retained their spatial structure under this suppression. The results indicate that the NBM contributes selectively to the global component of functional connectivity but plays little if any role in the specific correlations that define resting-state networks.<br/> </p><p>PMID: 29398365 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Fri, 01 May 2026 0:20:46 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator