http://www.nitrc.org/forum/forum.php?forum_id=8285 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=29441422">Related Articles</a></td></tr></table> <p><b>Mapping brain functional alterations in betel-quid chewers using resting-state fMRI and network analysis.</b></p> <p>Psychopharmacology (Berl). 2018 Feb 13;:</p> <p>Authors: Weng JC, Chou YS, Huang GJ, Tyan YS, Ho MC</p> <p>Abstract<br/> RATIONALE: The World Health Organization regards betel quid (BQ) as a human carcinogen, and DSM-IV and ICD-10 dependence symptoms may develop with its heavy use. BQ's possible effects of an enhanced reward system and disrupted inhibitory control may increase the likelihood of habitual substance use.<br/> OBJECTIVES: The current study aimed to employ resting-state fMRI to examine the hypothesized enhanced reward system (e.g., the basal forebrain system) and disrupted inhibitory control (e.g., the prefrontal system) in BQ chewers.<br/> METHODS: The current study recruited three groups of 48 male participants: 16 BQ chewers, 15 tobacco- and alcohol-user controls, and 17 healthy controls. We used functional connectivity (FC), mean fractional amplitude of low-frequency fluctuations (mfALFF), and mean regional homogeneity (mReHo) to evaluate functional alternations in BQ chewers. Graph theoretical analysis (GTA) and network-based statistical (NBS) analysis were also performed to identify the functional network differences among the three groups.<br/> RESULTS: Our hypothesis was partially supported: the enhanced reward system for the BQ chewers (e.g., habitual drug-seeking behavior) was supported; however, their inhibitory control was relatively preserved. In addition, we reported that the BQ chewers may have enhanced visuospatial processing and decreased local segregation.<br/> CONCLUSIONS: The current results (showing an enhanced reward system in the chewers) provided the clinicians with important insight for the future development of an effective abstinence treatment.<br/> </p><p>PMID: 29441422 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Thu, 30 Apr 2026 13:26:42 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator