http://www.nitrc.org/forum/forum.php?forum_id=8651 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=29859948">Related Articles</a></td></tr></table> <p><b>Pre-treatment functional MRI of breast cancer: T2* evaluation at 3 T and relationship to dynamic contrast-enhanced and diffusion-weighted imaging.</b></p> <p>Magn Reson Imaging. 2018 May 31;:</p> <p>Authors: Kousi E, O'Flynn EAM, Borri M, Morgan VA, de Souza NM, Schmidt MA</p> <p>Abstract<br/> PURPOSE: Baseline T2* relaxation time has been proposed as an imaging biomarker in cancer, in addition to Dynamic Contrast-Enhanced (DCE) MRI and diffusion-weighted imaging (DWI) parameters. The purpose of the current work is to investigate sources of error in T2* measurements and the relationship between T2* and DCE and DWI functional parameters in breast cancer.<br/> METHODS: Five female volunteers and thirty-two women with biopsy proven breast cancer were scanned at 3 T, with Research Ethics Committee approval. T2* values of the normal breast were acquired from high-resolution, low-resolution and fat-suppressed gradient-echo sequences in volunteers, and compared. In breast cancer patients, pre-treatment T2*, DCE MRI and DWI were performed at baseline. Pathologically complete responders at surgery and non-responders were identified and compared. Principal component analysis (PCA) and cluster analysis (CA) were performed.<br/> RESULTS: There were no significant differences between T2* values from high-resolution, low-resolution and fat-suppressed datasets (p &gt; 0.05). There were not significant differences between baseline functional parameters in responders and non-responders (p &gt; 0.05). However, there are differences in the relationship between T2* and contrast-agent uptake in responders and non-responders. Voxels of similar characteristics were grouped in 5 clusters, and large intra-tumoural variations of all parameters were demonstrated.<br/> CONCLUSION: Breast T2* measurements at 3 T are robust, but spatial resolution should be carefully considered. T2* of breast tumours at baseline is unrelated to DCE and DWI parameters and contribute towards describing functional heterogeneity of breast tumours.<br/> </p><p>PMID: 29859948 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 26 Apr 2026 18:25:13 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator