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  <title>NITRC News Group Forum: language-function-shows-comparable-cortical-patterns-by-functional-mri-and-repetitive-ntms-in-healthy-volunteers.</title>
  <link>http://www.nitrc.org/forum/forum.php?forum_id=8772</link>
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	&lt;table border=&quot;0&quot; width=&quot;100%&quot;&gt;&lt;tr&gt;&lt;td align=&quot;left&quot;/&gt;&lt;td align=&quot;right&quot;&gt;&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;amp;cmd=Link&amp;amp;LinkName=pubmed_pubmed&amp;amp;from_uid=29981018&quot;&gt;Related Articles&lt;/a&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;
        &lt;p&gt;&lt;b&gt;Language function shows comparable cortical patterns by functional MRI and repetitive nTMS in healthy volunteers.&lt;/b&gt;&lt;/p&gt;          
        &lt;p&gt;Brain Imaging Behav. 2018 Jul 06;:&lt;/p&gt;
        &lt;p&gt;Authors:  Hauck T, Probst M, Zimmer C, Ringel F, Meyer B, Wohlschlaeger A, Krieg SM&lt;/p&gt;
        &lt;p&gt;Abstract&lt;br/&gt;
        In preoperative planning, fMRI and repetitive navigated transcranial magnetic stimulation (rTMS) repeatedly revealed differences in the detected language sites, which can be attributed to tumor-induced oxygenation changes impairing the accuracy of fMRI. We therefore compared the accordance of those techniques in healthy subjects using exactly the same tasks in both investigations. 19 healthy right-handed subjects performed object naming, pseudoword reading, verb generation, and action naming during fMRI at 3 T and rTMS. For rTMS language mapping, we stimulated 46 cortical spots over the left hemisphere; each site was stimulated for three times. Language positive points during rTMS for one, two, or three errors out the three stimulations per spot (1/3, 2/3, 3/3) were exported via DICOM, and compared to the positive fMRI clusters. As a result of this comparison, the best correlation was observed between 3/3 errors and fMRI for pseudoword reading and verb generation with t-values of pu &amp;lt; 0.001, uncorrected for multiple comparisons, on average across the whole rTMS-spot map. We found a close spatial agreement between several rTMS-spots (2/3 and 3/3 errors) and fMRI clusters accentuated in the frontal lobe, followed by the parietal lobe and less in the temporal lobe. Compared to the fMRI clusters, there was a higher congruence for 2/3 and 3/3 errors than for 1/3 errors. Overall, results of language mapping in healthy subjects by fMRI and rTMS correspond well yet depending on the used language task.&lt;br/&gt;
        &lt;/p&gt;&lt;p&gt;PMID: 29981018 [PubMed - as supplied by publisher]&lt;/p&gt;
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