http://www.nitrc.org/forum/forum.php?forum_id=8858 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=30045816">Related Articles</a></td></tr></table> <p><b>Goal Directed and Self-Control Systems in Bulimia Nervosa: An fMRI Study.</b></p> <p>EBioMedicine. 2018 Jul 22;:</p> <p>Authors: Neveu R, Neveu D, Carrier E, Gay A, Nicolas A, Coricelli G</p> <p>Abstract<br/> BACKGROUND: Binge eating is apparently the opposite of the strict control over food intake typically set by "maladaptive dieters". Using functional magnetic resonance imaging (fMRI), we investigated the role of goal-directed behaviors, and the related use of self-control, in binge-related food choices in patients with Bulimia Nervosa (BN).<br/> METHOD: While undergoing fMRI, women aged 18-35 with BN (N = 35) and healthy control women (N = 26) rated foods for healthiness and tastiness and then made food choices on a 5 points Likert scale between two conflicting options: one food with lower healthiness and higher tastiness (defined as uncontrolled choice) than the other food (defined as controlled choice).<br/> RESULTS: BN and healthy participants made more uncontrolled than controlled choices (63% vs 24% and 65% vs 18% respectively). While healthy participants used only food tastiness (chose tastier foods more often) to make food choices (p &lt; .001), BN patients used both food healthiness (chose unhealthy food more often, p &lt; .001) and food tastiness (p &lt; .001) to make binge-related food choices. Activity in the ventromedial prefrontal cortex (vmPFC), which correlated with food choices (pFWE = 0.02), reflected this difference in the integration of food healthiness and food tastiness into a decision value. Functional connectivity analysis showed that the activity in the dorsolateral prefrontal cortex was coupled with vmPFC activity in uncontrolled food choices (pFWE = 0.03).<br/> INTERPRETATION: Contrary to what might be expected, not only food tastiness but also unhealthiness (a more abstract cognitive-based attribute than food tastiness) plays a role in uncontrolled choices in BN. These choices are likely goal-directed behaviors and recruit self-control.<br/> </p><p>PMID: 30045816 [PubMed - as supplied by publisher]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 26 Apr 2026 16:15:21 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator