http://www.nitrc.org/forum/forum.php?forum_id=8923 <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;cmd=Link&amp;LinkName=pubmed_pubmed&amp;from_uid=30126367">Related Articles</a></td></tr></table> <p><b>A novel approach to monitoring the efficacy of anti-tumor treatments in animal models: combining functional MRI and texture analysis.</b></p> <p>BMC Cancer. 2018 Aug 20;18(1):833</p> <p>Authors: Meng M, Xue H, Lei J, Wang Q, Liu J, Li Y, Sun T, Xu H, Jin Z</p> <p>Abstract<br/> BACKGROUND: The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis.<br/> METHODS: Eighteen 4 T1 homograft tumor models were divided into control, paclitaxel monotherapy and paclitaxel and bevacizumab combination therapy groups (n = 6) that underwent multi-b-value DWI, DCE-MRI and texture analysis before and 15 days after treatment.<br/> RESULTS: After treatment, the tumors in the control group were significantly larger than those in the combination group (P = 0.018). In multi-b-value DWI, the ADCslow obviously increased in the combination group compared to that in the others (P &lt; 0.01). The f increased in the control and paclitaxel groups, but the combination group showed a significant decrease versus the others (P &lt; 0.02). Additionally, in DCE-MRI, the decreasing Ktrans showed an evident difference between the combination and control groups (P = 0.003) due to the latter's increasing Ktrans. The intra-group comparisons of tumor texture in pre-, mid- and post-treatments showed that the entropy had all significantly increased in all groups (P &lt; 0.01, SSF = 0-6), though the MPP, mean and SD increased only in the combination group (PMPP,mean,SD &lt; 0.05, SSF = 4-6). Moreover, the inter-group comparisons revealed that the mean and MPP exhibited significant differences after treatment (Pmean,MPP &lt; 0.05, SSF = 0-3).<br/> CONCLUSION: All these results suggest some strong correlations among DWI, DCE and texture analysis, which are beneficial for further study and clinical research.<br/> </p><p>PMID: 30126367 [PubMed - in process]</p> en-us Copyright 2000-2026 NITRC OSI Sun, 26 Apr 2026 13:01:16 GMT http://blogs.law.harvard.edu/tech/rss NITRC RSS generator