Dear all,

I am using LesionTOADS to calculate brain volume measures as well as Lesion Volume in MS Patients but to manual approach of the MRI I always have a significantly higher volume for Lesion Volume when running the tool. Sometimes by over 500% difference.

Does anybody have suggestions which parameters / settings should be changed to avoid this?

Thank you

Mike

LeasionTOADS Settings:

• (inAtlas) Atlas with Lesions.....
• (inOutput) Output images: Hard segmentation of lesions + sulcal CSF, filled WM and cortical GM memberships as well as filled WM mask. (CRUISE inputs).....
• (inMaximum) Maximum distance from the interventricular WM boundary to downweight the lesion membership to avoid false postives: .........
• (inMaximum2) Maximum ventricle distance: ........
• (inMaximum3) Maximum interventricular distance: .....
• (inAtlas5) Controls the effect of the statistical atlas on the segmentation: ..........
• (inSmooting) Controls the effect of neighberhood voxels on the membership: ........
• (inMaximum4) Maximum amount of relative change in the energy function considered as the convergence criteria: ........
• (inMaximum5) Maximum iterations: .....
• (inAtlas6) Atlas alignment: ......
• (inConnectivity) Connectivity (foreground,background): .......