help > F test for a two-tailed t test
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Feb 15, 2018  12:02 PM | Alejandro Cosa
F test for a two-tailed t test
Dear NBS experts,
My experimental design consist in two experimental groups and we are interested in identifiyng that subnetwork significantly different between groups. My question is: 
Despite the natural choice would be a ttest, is a F test suitable in the situation we dont hypothesize about the sign of the changes and increases in some subnetwork edges can be accompanied by a decrease in others?
Thanks very much in advance for your response.
Best whises, 
Alejandro
Feb 16, 2018  06:02 AM | Andrew Zalesky
RE: F test for a two-tailed t test
Hi Alejandro,

Yes - F-test is perfectly fine and your interpretation is correct. In this context, F-test is a two-sided alternative hypothesis, whereas t-test is one-sided.

Andrew

Originally posted by Alejandro Cosa:
Dear NBS experts,
My experimental design consist in two experimental groups and we are interested in identifiyng that subnetwork significantly different between groups. My question is: 
Despite the natural choice would be a ttest, is a F test suitable in the situation we dont hypothesize about the sign of the changes and increases in some subnetwork edges can be accompanied by a decrease in others?
Thanks very much in advance for your response.
Best whises, 
Alejandro
Feb 16, 2018  09:02 AM | Alejandro Cosa
RE: F test for a two-tailed t test
Dear Andrew,
Thanks a lot for your response.
Alejandro