Hi all,

I have a naive question about the interpretation of the meta-regression results.

I have significant regions for the contrast patients > controls (Z positive) and regions for the contrast controls > patients (Z negative).

How can I interprete it with my regressor ? Does it increase the effect of the contrast (if the score of my regressor increase the contrast increase) ? Is there another way to interprete it (I don't know how to interprete the negative estimate for deactivation: when the regressor increases, the deactivation increases ? or decreases ?)

In another way, how can I know the way of the interaction ?

Than you for your help

AL

Dear Arnaud,

The interpretation might be as follows:

- If a region shows patients > controls in the main analysis and the regressor is positive, we may conclude that the regressor increases the difference patients > controls.

- If a region shows patients > controls in the main analysis and the regressor is negative, we may conclude that the regressor decreases the difference patients > controls.

- If a region shows patients < controls in the main analysis and the regressor is negative, we may conclude that the regressor increases the difference patients < controls.

- If a region shows patients < controls in the main analysis and the regressor is positive, we may conclude that the regressor decreases the difference patients < controls.

I hope this helps.

Joaquim