Hello,

Conn does a seed level FDR correction. For a given seed, the correction would depend on all the other seed-to-target correlations (actually Fisher transformed correlation coefficients) for that particular seed (from which you would get your T and p values). Therefore, A-B correlation may be significant when looking at seed A but not vice-versa when looking at seed B as the correction applied is different. Hope that clears it up!


Best
Pravesh
Originally posted by Mathilde Kennis: