Hi,

I wanted to start by thanking everyone involved for the creation of NBS.

I was hoping to ask whether NBS can be utilized to compare structural covariance matrices between groups, in scenarios where only 1 matrix exists per group.

I have detailed my current approach below, which does lead to the cycling of Permutations up to 5000, for example; however, the "Max Size Random", "Max Size Actual", and "Lowest p-value" columns stay stagnant at 0.0, 0.0, and 1.0, respectively, despite any manipulation of the "Threshold" and "Significance" parameters.

Trying to compare two matrices (e.g. patients vs controls), I set:

Design Matrix to a path to a .txt file that contains:
0 1
1 0

Statistical Test to "t-test"
Contrast to [-1,1] or [1,-1]
Connectivity Matrices to a path to the first of two .txt files containing 20x20 covariance matrices (simply Pearson correlations)
Method to "Network-Based Statistic"
Component Size to "Extent"

Any potential advice that might be offered in this regard would be extremely appreciated.

Thank you very much for your time and assistance,
Eric